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|
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Some important
information about drugs measured is below:
|
Drug
|
Reference Unit
|
Methods
|
|
Carbamazepine
|
4-10 mg/ml
|
FPIA, TDx
|
|
Phenobarbital
|
10-25 mg/ml
|
FPIA, TDx
|
|
Phenitoin
|
10-20 mg/ml
|
FPIA, TDx
|
|
Methotrexate
|
5-10 mmol/L 24. h
----------------------------------
0,5-1.0 mmol/L 48. h
----------------------------------
<0,2 mmol/L 72. h
|
FPIA, TDx
|
|
Everolimus
|
--- ng/ml
|
FPIA, TDx
|
|
Tacrolimus
|
5-20 ng/ml
|
CEDIA
|
|
Cyclosporin
|
150-500 ng/ml
|
CEDIA
|
|
Micofenolic Acide
|
--- mg/ml
|
CEDIA
|
|
Digoxin
|
0,8-2 ng/ml
|
CEDIA
|
|
Valproic Acid
|
50-100 mg/ml
|
CEDIA
|
|
Trycyclic Antidepressant
|
>300 ng/ml, toxic concentration
|
CEDIA
|
|
Amphetamine
|
<1000 ng/ml negative
(serum, urine)
----------------------------------
>1000 ng/ml pozitive
(serum, urine)
|
CEDIA
|
|
Opiates
|
<50 ng/ml negative (serum)
-------------------------------------
>50 ng/ml pozitive (serum)
-------------------------------------
<300 ng/ml negative (urine)
-------------------------------------
>300 ng/ml pozitive (urine)
|
CEDIA
|
|
Cannabinoides
|
<50 ng/ml negative
(serum, urine)
-------------------------------------
>50 ng/ml pozitive (serum,
urine)
|
CEDIA
|
|
Benzodiazepine
|
--- ng/ml (urine)
|
CEDIA
|
|
Amicacine
|
--- mg/ml
|
CEDIA
|
|
Gentamycine
|
--- mg/ml
|
CEDIA
|
|
Acetaminophene
|
--- mg/ml
|
CEDIA
|
FPIA : Fluorescence
Polarization Immunoassay
CEDIA :
Cloned Enzyme Donor Immunoassay
CAUTION:
References values for
cyclosporin, tacrolimus and methotrexate given above is only for general
cases. The values measured should be evaluated by the doctors. i.e. reference
value for cyclosporin given above is valid for stabil
kidney disease, but the values may be higher for the patients who is operated
for bone marrow trasplants.
The values measured
which is not given a reference values above should be evaluated by the concerning
doctors.
Blood samples for methotrexate analysis should be kept
in dark. i.e. sample could be enveloped by aluminum
foil. In addition it should be noted for laboratory;
- When blood samples
were taken after the drug (24-36-42-48. h)
- Expected values (0-1, 1-10, 10-100,
100-1000 µgr/mL)
 Therapeutic Drug Monitoring
Laboratory
The links for information about drugs:
www.drugs.com
www.rxlist.com
Chemicals
for research
Vademecum
Pharmalist
|
